Triethylamine → HCID 58168471, 화합물

HRID 446428노트

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HRID 446428 반응식
CN([C:4]([O:8]N1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH2:25]([C:27]1[S:28][CH:29]=[C:30]([C:32]([N:34]2[CH2:39][C:38]3([CH2:44][CH2:43][N:42]([CH2:45][CH2:46][C:47]4[CH:60]=[CH:59][C:50]([CH2:51][CH2:52][O:53][CH2:54][CH2:55]C(O)=O)=[CH:49][CH:48]=4)[CH2:41][CH2:40]3)[O:37][CH2:36][CH2:35]2)=[O:33])[N:31]=1)[CH3:26].[CH3:61][O:62][CH:63]([O:69][CH3:70])[CH2:64][NH:65][CH2:66][CH2:67][CH3:68].C(N(CC)CC)C>ClCCl>[CH3:61][O:62][CH:63]([O:69][CH3:70])[CH2:64][N:65]([CH2:66][CH2:67][CH3:68])[C:4](=[O:8])[CH2:55][CH2:54][O:53][CH2:52][CH2:51][C:50]1[CH:49]=[CH:48][C:47]([CH2:46][CH2:45][N:42]2[CH2:41][CH2:40][C:38]3([O:37][CH2:36][CH2:35][N:34]([C:32]([C:30]4[N:31]=[C:27]([CH2:25][CH3:26])[S:28][CH:29]=4)=[O:33])[CH2:39]3)[CH2:44][CH2:43]2)=[CH:60][CH:59]=1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 12555585N-(2,2-Dimethoxyethyl)propan-1-amineHCID 58168480HCID 58168480, 화합물

생성물 1

HCID 58168471HCID 58168471, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

HATU (0.33 g) was added to a solution of 3-(4-(2-(4-(2-ethylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid [Example 3, step e] in (0.50 g), N-(2,2-dimethoxyethyl)propan-1-amine [Liebigs Annalen der Chemie 1979, 11, 1818]. (0.12 g) and triethylamine (0.56 mL) in dichloromethane (5 mL) at 0° C. under nitrogen, and the mixture stirred at ambient temperature for 2 hours. The mixture was washed with water, the organic phase was separated, dried, filtered and concentrated in vacuo to afford the subtitled compound as an orange oil. Yield 0.43 g.

후처리

  1. washThe mixture was washed with water
  2. customthe organic phase was separated
  3. customdried
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-cac7b7f36a504a6da45f41a63fb73550
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476265B2

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