Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → tert-butoxycarbonyl-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | O-benzotriazol-1-yl-tetramethyluronium | HCID 130500 | — |
| 반응물 | (S)-2-(Boc-amino)-2-phenylpropanoic acid | HCID 13678038 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | tert-butoxycarbonyl-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine | HCID 57444165 | 88% |
반응 단계
630 mg (2.374 mmol) of N-(tert-butoxycarbonyl)-2-phenyl-D-alanine were dissolved in 20 mL of dry DMF and O-(benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoborate (TBTU, 1.37 g, 4.27 mmol), morpholine (0.412 mL, 4.73 mmol) and diisopropylethylamine (1.63 mL, 9.5 mol) were added. The mixture was stirred at room temperature for 1 hour, then the solvent was removed and the residue dissolved with dichloromethane. The solution was washed with saturated NaHCO3, brine, water and dried over Na2SO4. 700 mg of the title compound were recovered (88% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541429B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-b8729780c0e546f6bf715a96e00cab8d |
| 출처 메모 | uspto-grants-2013_09 |