HCID 86663435, 화합물 → HCID 86663437, 화합물

HRID 446527노트

반응식

HRID 446527 반응식
O=[CH:2][CH2:3][O:4][CH2:5][CH2:6][C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([N:23]([CH3:36])[CH2:24][CH2:25][CH2:26][N:27]([CH3:35])[C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:22])=[CH:17][CH:16]=1>>[C:30]([O:29][C:28]([N:27]([CH3:35])[CH2:26][CH2:25][CH2:24][N:23]([CH3:36])[C:21]([C:18]1[CH:19]=[CH:20][C:15]([NH:14][CH2:2][CH2:3][O:4][CH2:5][CH2:6][C:7]([O:9][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:8])=[CH:16][CH:17]=1)=[O:22])=[O:34])([CH3:32])([CH3:31])[CH3:33]

참가 물질

3

반응물 2

HCID 86663435HCID 86663435, 화합물HCID 86663438CHO-PEG1-COOtBu

생성물 1

HCID 86663437HCID 86663437, 화합물수율 83%

실험 절차

The compound (87 mg, 0.461 mmol) obtained in Example 28b and the compound (150 mg, 0.461 mmol) obtained in Example 28d were used to give the title compound (188 mg; yield, 83%) as a colorless oily substance according to the method described in Example 18b.

출처 및 근거

ORD 기록
ord-9832baf92a62409fbd7d522ee9d048c3
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476253B2

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