(6-Methylpyridin-2-yl)methanol hydrochloride → 2-(Chloromethyl)-6-methylpyridine
반응식
[ClH:1].[CH3:2][C:3]1[N:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][CH:4]=1>O=S(Cl)Cl>[Cl:1][CH2:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([CH3:2])[N:8]=1참가 물질
3
실험 절차
A solution of (6-methylpyridin-2-yl)methanol hydrochloride (1.0 g, 0.008 mol) in SOCl2 (3 mL) was stirred at RT for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was azeotroped with toluene and the resulting residue was filtered and dried in vacuo to afford 2-(chloromethyl)-6-methylpyridine (800 mg, 63%) as a light brown solid.
후처리
- concentrationThe reaction mixture was then concentrated in vacuo
- customto obtain the crude product
- customThe crude material was azeotroped with toluene
- filtrationthe resulting residue was filtered
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-d56dcbc7c9984717852394e78b9c4ed7
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481534B2
반응 노트
불러오는 중…