(6-Methylpyridin-2-yl)methanol hydrochloride → 2-(Chloromethyl)-6-methylpyridine

HRID 446816

반응식

HRID 446816 반응식
[ClH:1].[CH3:2][C:3]1[N:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][CH:4]=1>O=S(Cl)Cl>[Cl:1][CH2:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([CH3:2])[N:8]=1

참가 물질

3

반응물 1

HCID 18413908(6-Methylpyridin-2-yl)methanol hydrochloride

생성물 1

HCID 765462-(Chloromethyl)-6-methylpyridine수율 70.6%

시약·촉매·용매 1

HCID 24386Thionyl Chloride용매

실험 절차

A solution of (6-methylpyridin-2-yl)methanol hydrochloride (1.0 g, 0.008 mol) in SOCl2 (3 mL) was stirred at RT for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was azeotroped with toluene and the resulting residue was filtered and dried in vacuo to afford 2-(chloromethyl)-6-methylpyridine (800 mg, 63%) as a light brown solid.

후처리

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customto obtain the crude product
  3. customThe crude material was azeotroped with toluene
  4. filtrationthe resulting residue was filtered
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-d56dcbc7c9984717852394e78b9c4ed7
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481534B2

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