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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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4-{2-[2-(tert-Butoxycarbonyl-methyl-amino)-propionylamino]-2-cyclohexyl-acetyl}-3-phenylcarbamoyl-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester → {1-[1-Cyclohexyl-2-oxo-2-(6-phenylcarbamoyl-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl)-ethylcarbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester

HRID 446979
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인쇄 미리보기

반응식

HRID 446979 반응식
C(OC([N:11]1[CH2:15][CH:14]([C:16](=[O:24])[NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:13]2[N:25]([C:28](=[O:50])[CH:29]([NH:36][C:37](=[O:49])[CH:38]([N:40]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH3:41])[CH3:39])[CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[CH2:26][CH2:27][CH:12]12)=O)C1C=CC=CC=1>CO.[Pd]>[C:45]([O:44][C:42](=[O:43])[N:40]([CH:38]([C:37](=[O:49])[NH:36][CH:29]([CH:30]1[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1)[C:28](=[O:50])[N:25]1[CH2:26][CH2:27][CH:12]2[NH:11][CH2:15][CH:14]([C:16](=[O:24])[NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:13]12)[CH3:39])[CH3:41])([CH3:46])([CH3:47])[CH3:48]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 1

HCID 672822034-{2-[2-(tert-Butoxycarbonyl-methyl-amino)-propionylamino]-2-cyclohexyl-acetyl}-3-phenylcarbamoyl-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

생성물 1

HCID 67280553{1-[1-Cyclohexyl-2-oxo-2-(6-phenylcarbamoyl-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl)-ethylcarbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887
Methanol
용매

실험 절차

A mixture of 41 (440 mg, 0.64 mmol) and 10% palladium-on-carbon (88 mg) in MeOH (15 mL) was shaken at 48 psi under a H2 atmosphere. After 2 h, the mixture was filtered through a 0.45 μM filtering disc, washed with MeOH and concentrated to afford 42 (352 mg) as a white foam that was used without further purification. Mass spectrum, m/z [556.6] (M+H)+.

후처리

  1. filtrationthe mixture was filtered through a 0.45 μM
  2. filtrationfiltering disc
  3. washwashed with MeOH
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-18f0994eaa2c43fabf05b5f5f7c74e64
출처 데이터셋
uspto-grants-2013_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08481495B2

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