Water → HCID 49766558, 화합물

HRID 447050노트

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HRID 447050 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11].[Br:12]Br.O>C(Cl)Cl>[NH2:1][C:2]1[C:7]([Br:12])=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 49847212-Amino-5-Nitrophenol

생성물 1

HCID 49766558HCID 49766558, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To an ice-cold solution of 2-amino-5-nitro phenol (40.0 g, 259.52 mmol) in DCM (1.0 L), was added bromine (13.38 mL, 259.52 mmol) drop wise. The resulting reaction mixture was stirred at room temperature for 45 min. After the completion of the reaction (TLC monitoring), water was added and extracted with EtOAc (3×1.0 L). The combined organics was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude (55.0 g, 92%) was carried forward to the next step without further purification.

후처리

  1. customThe resulting reaction mixture
  2. additionwas added
  3. extractionextracted with EtOAc (3×1.0 L)
  4. dry with materialThe combined organics was dried over anhydrous Na2SO4
  5. concentrationconcentrated under reduced pressure
  6. customThe crude (55.0 g, 92%) was carried forward to the next step without further purification

출처 및 근거

ORD 기록
ord-ccc715c7f9624efbb093031d5b468986
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481544B2

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