Dimethylmaleic anhydride → 4,5-Dimethylpyridazine-3,6-diol

HRID 447104

반응식

HRID 447104 반응식
Cl.[NH2:2][NH2:3].[CH3:4][C:5]1=[C:6]([CH3:12])[C:7]([O:9][C:10]1=O)=[O:8]>O>[CH3:4][C:5]1[C:10](=[O:9])[NH:2][NH:3][C:7](=[O:8])[C:6]=1[CH3:12]

참가 물질

4

반응물 2

HCID 13010Dimethylmaleic anhydrideHCID 115031Hydrazinium chloride

생성물 1

HCID 2422804,5-Dimethylpyridazine-3,6-diol수율 99.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The suspension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40° C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99%).

후처리

  1. temperatureat reflux for 16 h
  2. filtrationthe precipitate is filtered
  3. washwashed with water
  4. customdried at 40° C. under vacuum

출처 및 근거

ORD 기록
ord-0327013cf966424c9a9f534b8b90572f
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481542B2

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