3,5-Difluoropyridine → 3-[4-(2-Chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-5-fluoro-pyridine

HRID 447183

반응식

HRID 447183 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.[F:16][C:17]1[CH:18]=[N:19][CH:20]=[C:21](F)[CH:22]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[N:13]([C:21]3[CH:20]=[N:19][CH:18]=[C:17]([F:16])[CH:22]=3)[CH:14]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 6428203,5-DifluoropyridineHCID 178418879HCID 178418879, 화합물

생성물 1

HCID 249913983-[4-(2-Chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-5-fluoro-pyridine

실험 절차

The title compound, MS: m/e=313.1 (M+H+), was prepared in accordance with the general method of example 3 from 2-chloro-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 3,5-difluoro-pyridine.

출처 및 근거

ORD 기록
ord-e697c18ffa1e4595889dda0852f82894
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481548B2

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