Dichloromethane → HCID 20689421, 화합물

HRID 447538노트

반응식

HRID 447538 반응식
[Br:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.C(Cl)Cl.C(O)(C(F)(F)F)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)=[CH:20][CH:21]=1

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 10760574Tert-butyl 4-(4-bromobenzyl)piperidine-1-carboxylate

생성물 1

HCID 20689421HCID 20689421, 화합물수율 93%

실험 절차

To a solution of tert-butyl 4-(4-bromobenzyl)piperidine-1-carboxylate (780 mg, 2.2 mmol) in CH2Cl2 (15 mmol), was added TFA (0.5 mL) and the mixture was stirred at rt for 1 h. The solvent was removed in vacuo and the residue dissolved into CH2Cl2 (50 mL), washed with NaOH (0.1 M, 10 mL), brine (10 mL), dried over MgSO4 and concentrated to dryness to give the title compound as a beige solid (520 mg, 93%).

후처리

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue dissolved into CH2Cl2 (50 mL)
  3. washwashed with NaOH (0.1 M, 10 mL), brine (10 mL)
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-77409a7a9ef44bada38ec9add6197bec
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481525B2

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