Ammonia → 4,5-Pyrimidinediamine, 6-chloro-

반응식

[NH2:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[N:6][C:7]=1[Cl:8].[NH3:10]>>[Cl:8][C:7]1[N:6]=[CH:5][N:4]=[C:3]([NH2:10])[C:2]=1[NH2:1]

참가 물질

반응물 2

HCID 222Ammonia

HCID 794345-Amino-4,6-dichloropyrimidine

생성물 1

HCID 780104,5-Pyrimidinediamine, 6-chloro-

반응 조건

온도: 118 °C

실험 절차

A suspension of 5-Amino-4,6-dichloropyrimidine (3 g, 0.02 mol) in ammonia (25 mL, 7N/MeOH, 0.175 mole) was heated at 118° C. overnight(under pressure). The reaction was cooled to 23° C., filtered and washed with ethanol to obtain 1.92 g (70%).

후처리

temperatureThe reaction was cooled to 23° C.
filtrationfiltered
washwashed with ethanol
customto obtain 1.92 g (70%)

출처 및 근거

ORD 기록: ord-b09411bf28e54028a37863fd5808ffc7
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08481550B2

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