Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-(Ethylsulfanyl)-5-methylbenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Fluoro-5-methylbenzonitrile | HCID 2774584 | — |
| 반응물 | Sodium ethanethiolate | HCID 4459711 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(Ethylsulfanyl)-5-methylbenzonitrile | HCID 66877145 | 87.1% |
반응 단계
(Step 1) A mixture of 2-fluoro-5-methylbenzonitrile (7.5 g) and sodium ethanethiolate (4.9 g) was stirred in N,N-dimethylformamide (30 ml) at room temperature for 3 hr. The reaction solution was treated with 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give 2-(ethylsulfanyl)-5-methylbenzonitrile (8.57 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08481569B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-335dd0ffdb9d42afbf7618b7a5188e88 |
| 출처 메모 | uspto-grants-2013_07 |