Phenyl isocyanate → Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

HRID 4481노트

반응식

HRID 4481 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH:5]2[C:12]([O:14][CH3:15])=[O:13].[C:16]1([N:22]=[C:23]=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1(C)C=CC=CC=1>[C:16]1([NH:22][C:23]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=3)[CH:5]([C:12]([O:14][CH3:15])=[O:13])[C:6]2=[O:11])=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 21282067methyl 5-chloro-2-oxo-2,3-dihydro-1H-indole-3-carboxylate

생성물 1

HCID 14097011Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To 6.0 g. (0.027 mole) of methyl 5-chlorooxindole-3-carboxylate in 200 ml. of toluene was added 5.25 ml. (0.048 mole) of phenylisocyanate and the resulting reaction mixture heated to reflux overnight. The reaction mixture was cooled and diluted with petroleum ether to give, after filtration and drying, 2.0 g. of the desired product.

후처리

  1. temperatureheated
  2. temperatureto reflux overnight
  3. temperatureThe reaction mixture was cooled
  4. customto give
  5. filtrationafter filtration
  6. customdrying

출처 및 근거

ORD 기록
ord-bbeceddc0faf432ab9c414f3a0a0c3be
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725616

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