Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylsilyldiazomethane → 1-Benzyl 4-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 반응물 | N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid | HCID 2756777 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-Benzyl 4-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate | HCID 4451965 | — |
반응 단계
1-(Benzyloxycarbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (1-JJ, 1.07 g, 2.9 mmol, Small Molecules, Inc., Hoboken, N.J. USA) was dissolved in 10 mL of dry methanol and trimethylsilyl diazomethane (2.0 M in diethyl ether, Aldrich) was added dropwise with stirring at rt until a slight yellow color persisted. The solution was then concentrated under reduced pressure, and flash chromatography (0-50% EtOAc/hexanes elution) gave 1-benzyl 4-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate (compound II-JJ) as a colorless oil: [M+Na]+=401.2 (35%); [M-Boc+H]+=279.1 (100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541418B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-a8fddb8885d34600a6f07993de8b5f10 |
| 출처 메모 | uspto-grants-2013_09 |