Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-(1-Methoxycarbonylethoxy)benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Methyl 2-bromopropionate | HCID 95576 | — |
| 반응물 | 2-Hydroxybenzene-1-sulfonamide | HCID 637546 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-(1-Methoxycarbonylethoxy)benzenesulfonamide | HCID 22152837 | 80.7% |
반응 단계
34.6 g of 2-hydroxybenzenesulfonamide and 55.3 g of potassium carbonate are added to 800 ml of acetonitrile. With efficient stirring, 33.4 g of methyl 2-bromopropionate are added dropwise over 10 minutes and the suspension is then heated for 5 hours to 45° C. After the reaction mixture has cooled, the precipitated salts are isolated and the filtrate is concentrated in vacuo. The residue is recrystallised from ethanol, affording 41.8 g of 2-(1-methoxycarbonylethoxy)- benzenesulfonamide with a melting point of 140°-142° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04726836 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-580394b4ef7a438bb6f3a79f841eee23 |
| 출처 메모 | uspto-grants-1988_02 |