2-(3,4-difluorophenyl)-1H-imidazole → HCID 58405949, 화합물

반응식

Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]3[CH2:19][CH:18]([F:20])[CH2:17]3)[C:4]=2[N:3]=1.[F:21][C:22]1[CH:23]=[C:24]([C:29]2[NH:30][CH:31]=[CH:32][N:33]=2)[CH:25]=[CH:26][C:27]=1[F:28]>>[F:21][C:22]1[CH:23]=[C:24]([C:29]2[N:33]([C:2]3[N:11]=[CH:10][C:9]4[N:8]([CH3:12])[C:7](=[O:13])[C@@H:6]([CH2:14][CH3:15])[N:5]([CH:16]5[CH2:19][CH:18]([F:20])[CH2:17]5)[C:4]=4[N:3]=3)[CH:32]=[CH:31][N:30]=2)[CH:25]=[CH:26][C:27]=1[F:28]

참가 물질

반응물 2

HCID 584053162-(3,4-difluorophenyl)-1H-imidazole

HCID 58405575HCID 58405575, 화합물

생성물 1

HCID 58405949HCID 58405949, 화합물

실험 절차

The title compound was prepared similarly to the methods described in Example 77, with Intermediate W instead of Intermediate C and with 2-(3,4-difluorophenyl)-1H-imidazole instead of 2-phenyl-1H-imidazole. LCMS: 443.1 m/z (M+H)+; ret. Time: 6.85 min (Analytical Method C).

출처 및 근거

ORD 기록: ord-e084b8d272ba40f390c3f25d8b109769
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08541418B2

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