Ammonia → HCID 66915610, 화합물
반응식
[Br:1][C:2]1[N:3]=[C:4]([I:12])[N:5]2[CH:10]=[CH:9][N:8]=[C:7](Cl)[C:6]=12.[NH3:13]>CC(O)C.O>[Br:1][C:2]1[N:3]=[C:4]([I:12])[N:5]2[CH:10]=[CH:9][N:8]=[C:7]([NH2:13])[C:6]=12참가 물질
5
반응 조건
- 온도
- 95 °C
실험 절차
To a stirred solution of 1-bromo-8-chloro-3-iodo-imidazo[1,5-a]pyrazine (250.00 mg, 0.696 mmol) in i-PrOH (8 mL) in a Parr bomb was added 7 mL ammonia in water (35%). The resulting solution was stirred at 95° C. overnight. The solvent was removed under reduced pressure and the crude material was passed through a short silica gel column (5% MeOH in DCM as eluent). The fractions were collected and combined, solvent was removed under reduced pressure to give a residue which was used in next step without further purification. MS (ES+): m/z: 338.80, 340.81 [MH+]. HPLC: tR=1.64 min (OpenLynx: polar—5 min).
후처리
- customThe solvent was removed under reduced pressure
- customThe fractions were collected
- customsolvent was removed under reduced pressure
- customto give a residue which
- customwas used in next step without further purification
- customHPLC: tR=1.64 min (OpenLynx: polar—5 min)
출처 및 근거
- ORD 기록
- ord-4dadfc2af14741009edba2a075bf4547
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481733B2
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