Hydroxyl phenylboronic acid acid → 4-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)phenol

반응식

[NH2:1][C:2]1[C:3]2[N:4]([C:8]([CH:20]3[CH2:23][CH2:22][CH2:21]3)=[N:9][C:10]=2[C:11]2[CH:12]=[CH:13][C:14](F)=[C:15]([CH:18]=2)C#N)[CH:5]=[CH:6][N:7]=1.[OH:24]OB(C1C=CC=CC=1)O>>[NH2:1][C:2]1[C:3]2[N:4]([C:8]([CH:20]3[CH2:23][CH2:22][CH2:21]3)=[N:9][C:10]=2[C:11]2[CH:12]=[CH:13][C:14]([OH:24])=[CH:15][CH:18]=2)[CH:5]=[CH:6][N:7]=1

참가 물질

반응물 2

HCID 58822967Hydroxyl phenylboronic acid acid

HCID 669156655-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)-2-fluorobenzonitrile

생성물 1

HCID 1361179304-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)phenol

실험 절차

Prepared according to a Suzuki coupling procedure analogous to that described for synthesis of 5-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)-2-fluorobenzonitrile, except using 4 hydroxyphenylboronic acid. MS (ES+): m/z 281.17 (100)[MH+].

후처리

customPrepared

출처 및 근거

ORD 기록: ord-36758896728142cabde9b7ce017efe23
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08481733B2

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