Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formic Acid → N-(5-Chloro-2-phenoxy-phenyl)-formamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formic Acid | HCID 284 | — |
| 반응물 | 5-Chloro-2-phenoxyaniline | HCID 66738 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(5-Chloro-2-phenoxy-phenyl)-formamide | HCID 12290068 | — |
반응 단계
A mixture of 1-amino-5-chloro-2-phenoxybenzene (1.00 g, 4.55 mmol), formic acid (0.34 mL, 9.10 mmol), TBTU (1.46 g, 4.55 mmol), DIEA (2.38 mL, 13.6 mmol) and DCM (20 mL) was stirred at rt for 2 h. The solution was transferred to a separatory funnel, 20 mL of sat. aq. NaHCO3 solution was added and the mixture was extracted DCM. The organics were combined and dried (Na2SO4). Solvent was removed under reduced pressure to give a crude residue which was purified via flash chromatography, eluting with 5% EtOAc in hexanes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08481733B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-e8058ec2bec9481493262bcce1b83675 |
| 출처 메모 | uspto-grants-2013_07 |