Phenylboronic Acid → 1-Bromo-4-phenoxy-2-(trifluoromethyl)benzene

HRID 449133노트

반응식

HRID 449133 반응식
[C:1]1(B(O)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=1[C:18]([F:21])([F:20])[F:19]>C(Cl)Cl>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:13][C:12]=1[C:18]([F:19])([F:20])[F:21]

참가 물질

4

반응물 2

HCID 66827Phenylboronic AcidHCID 222773074-Bromo-3-(trifluoromethyl)phenol

생성물 1

HCID 669156501-Bromo-4-phenoxy-2-(trifluoromethyl)benzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred mixture of phenylboronic acid (1.20 g, 9.85 mmol) and 4-bromo-3-trifluoromethyl-phenol (1.18 g, 4.92 mmol) in DCM (50.00 mL) was added cupric acetate (1.34 g, 7.39 mmol), powdered 4 A molecular sieves and TEA (3.43 mL, 24.6 mmol) at rt. The resulting mixture was then stirred at rt for 24 h at ambient atmosphere. The solvent was then removed under reduced pressure and the resulting residue was purified by flash chromatography (5% EtOAc in hexane).

후처리

  1. customat rt
  2. customThe solvent was then removed under reduced pressure
  3. customthe resulting residue was purified by flash chromatography (5% EtOAc in hexane)

출처 및 근거

ORD 기록
ord-d0f483d181af41c48e6df16766390bb5
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481733B2

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