참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 6-Quinolinecarboxylic acid | HCID 82571 | — |
| 생성물 | Methyl quinoline-6-carboxylate | HCID 736812 | 75% |
반응 단계
To a solution of quinoline-6-carboxylic acid (183 g, 1.06 mol) in methanol (1 lit.), thionyl chloride (150.7 g, 1.2 mol) was added dropwise at 0° C. and then stirred at 65° C. for 12 h. The reaction mixture was concentrated and to the residue dichloromethane and aqueous sodium carbonate solutions were added. The organic layer was dried with sodium sulphate and concentrated to afford the title compound as a brown solid (150 g, 75%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08481739B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_07 |
|---|
| ORD ID | ord-ec3613bb85b24e36809e4d5e4b97f0b8 |
|---|
| 출처 메모 | uspto-grants-2013_07 |
|---|
