Methanol → Methyl quinoline-6-carboxylate

HRID 449244

반응식

HRID 449244 반응식
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.S(Cl)(Cl)=O.[CH3:18]O>>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13][CH3:18])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 825716-Quinolinecarboxylic acid

생성물 1

HCID 736812Methyl quinoline-6-carboxylate수율 75%

반응 조건

온도
65 °C

실험 절차

To a solution of quinoline-6-carboxylic acid (183 g, 1.06 mol) in methanol (1 lit.), thionyl chloride (150.7 g, 1.2 mol) was added dropwise at 0° C. and then stirred at 65° C. for 12 h. The reaction mixture was concentrated and to the residue dichloromethane and aqueous sodium carbonate solutions were added. The organic layer was dried with sodium sulphate and concentrated to afford the title compound as a brown solid (150 g, 75%).

후처리

  1. concentrationThe reaction mixture was concentrated and to the residue dichloromethane and aqueous sodium carbonate solutions
  2. additionwere added
  3. dry with materialThe organic layer was dried with sodium sulphate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ec3613bb85b24e36809e4d5e4b97f0b8
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481739B2

연결된 노트

불러오는 중…