Aminoacetaldehyde dimethyl acetal → 7-Bromo-6-methylisoquinoline

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH3:10])[CH:5]=O.CO[CH:13](OC)[CH2:14][NH2:15]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:7]([CH:13]=[CH:14][N:15]=[CH:5]2)=[CH:8][C:9]=1[CH3:10]

참가 물질

반응물 2

HCID 89728Aminoacetaldehyde dimethyl acetal

HCID 8167653-Bromo-4-methylbenzaldehyde

생성물 1

HCID 594965897-Bromo-6-methylisoquinoline

실험 절차

This compound was prepared by using procedures analogous to those described for the synthesis of Example 75, Step 1 starting from 3-bromo-4-methylbenzaldehyde (Aldrich, Cat. #4017458) and. aminoacetaldehyde dimethyl acetal. Analytic LCMS (M+H)+: m/z=221.95/223.95.

후처리

customThis compound was prepared

출처 및 근거

ORD 기록: ord-66fcfe8a5a6d463f9b6baa757d41bd3f
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08481732B2

반응 노트

불러오는 중…