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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 449418생성일: 2026년 10월 26일

4-Phenoxyphenyl isocyanate → 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(4-phenoxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

https://huagongshe.com/reaction/449418

반응식

참여 물질

역할이름HCID투입량
반응물4-Phenoxyphenyl isocyanateHCID 2734896—
반응물4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl saltHCID 67541489—
생성물7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(4-phenoxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamideHCID 49779705—

반응 단계

This compound was prepared by using procedures analogous to those described for the synthesis of Example 5 starting from 4-phenoxyphenyl isocyanate (Aldrich, Cat. #478970) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=536.2.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08481732B2
출처 데이터셋uspto-grants-2013_07
ORD IDord-2077a0a743584dceadb3f3f808a5de4c
출처 메모uspto-grants-2013_07