Trifluoroacetic acid → (S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate

HRID 449485노트

반응식

HRID 449485 반응식
FC(F)(F)C(O)=O.[C:8]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:13]=[CH:12][C:11]([CH2:14][C@H:15]([NH:20]C(OC(C)(C)C)=O)[C:16]([O:18][CH3:19])=[O:17])=[CH:10][CH:9]=1>C(Cl)Cl>[NH2:20][C@@H:15]([CH2:14][C:11]1[CH:12]=[CH:13][C:8]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:9][CH:10]=1)[C:16]([O:18][CH3:19])=[O:17]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 10286882(S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate

생성물 1

HCID 15714801(S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate수율 139.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (1 mL, 10 mmol) was added to a solution of (S)-methyl 3-(biphenyl-4-yl)-2-(tert-butoxycarbonylamino)propanoate (30 mg) in methylene chloride (2 mL). The reaction was stirred for 1 h, and was concentrated under reduced pressure to give the crude product methyl (2S)-2-amino-3-biphenyl-4-ylpropanoate (30 mg, 100%). Analytical LCMS (M+H)+: m/z=256.1.

후처리

  1. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-bfb890ae30d6422a97b9fc386f1177f8
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481732B2

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