Isoquinolin-5-ol → 1,2,3,4-Tetrahydroisoquinolin-5-ol
반응식
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1>C(O)(=O)C>[CH2:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:11])[C:5]=2[CH2:4][CH2:3][NH:2]1참가 물질
3
실험 절차
Isoquinolin-5-ol (Aldrich, Cat. #H33207)(0.75 g, 5.2 mmol) was dissolved in acetic acid (20.0 mL) in a Parr shaker bottle. The reaction was degassed with nitrogen, and the platinum dioxide (0.050 g) was added. The reaction was charged to 55 Psi hydrogen and shaken. After shaking for 24 h. the reaction was complete. This was filtered to remove the catalyst and concentrated under reduced pressure give a dark amber 1,2,3,4-tetrahydroisoquinolin-5-ol (0.70 g, 90%) as an oil. Analytical LCMS (M+H)+: m/z=150.1.
후처리
- customThe reaction was degassed with nitrogen
- additionthe platinum dioxide (0.050 g) was added
- additionThe reaction was charged to 55 Psi hydrogen
- stirringAfter shaking for 24 h. the reaction
- filtrationThis was filtered
- customto remove the catalyst
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-57265a60d78f4d2fae3da2db3afff653
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481732B2
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