1-Isopropyl-4-(6-nitropyridin-3-yl)piperazine → 5-(4-(Propan-2-yl)piperazin-1-yl)pyridin-2-amine

HRID 449609노트

반응식

HRID 449609 반응식
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:11]=[N:12][C:13]([N+:16]([O-])=O)=[CH:14][CH:15]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]>CCO.[Pd]>[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12][CH:11]=2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 575020971-Isopropyl-4-(6-nitropyridin-3-yl)piperazine

생성물 1

HCID 434619445-(4-(Propan-2-yl)piperazin-1-yl)pyridin-2-amine수율 61.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

In a 250 mL round-bottomed flask, 1-isopropyl-4-(6-nitropyridin-3-yl)piperazine (788 mg, 3.15 mmol, Eq: 1.00) in EtOH (40 ml) was combined with palladium on carbon (DeGussa)(78.2 mg, 735 μmol, Eq: 0.233). The mixture was evacuated twice with hydrogen and then stirred under a hydrogen atmosphere for 18 h. The solution was filtered through celite, rinsing the celite with fresh ethanol. The solvent was evaporated under reduced pressure to give 5-(4-isopropylpiperazin-1-yl)pyridin-2-amine (425 mg, 61%). LC/MS-ESI observed [M+H]+ 221.

후처리

  1. customThe mixture was evacuated twice with hydrogen
  2. filtrationThe solution was filtered through celite
  3. washrinsing the celite with fresh ethanol
  4. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-141944ccc63f4873b599b9cf47ff11dc
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481540B2

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