HCID 66742608, 화합물 → 5-(4-Methylpiperazin-1-YL)pyrazin-2-amine
반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[N:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=2)[CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:13]=[N:12][C:11]([NH2:14])=[CH:10][N:9]=2)[CH2:6][CH2:7]1참가 물질
4
실험 절차
2-(4-methylpiperazin-1-yl)-5-nitropyrazine (328 mg, 1.47 mmol) was dissolved in MeOH (15 ml) at room temperature. Pd/C (10%) (50 mg) was added while the reaction mixture was stirred. The reaction mixture was placed under a H2 balloon and stirred at rt for 1.5 hrs. The reaction mixture was filtered through celite and washed with MeOH (30 mL). The filtrate was stripped and dried under vacuum after azeotroping with toluene twice to give a light brown gummy material (280 mg, yield 89%).
후처리
- stirringstirred at rt for 1.5 hrs
- filtrationThe reaction mixture was filtered through celite
- washwashed with MeOH (30 mL)
- customdried under vacuum
- customafter azeotroping with toluene twice
출처 및 근거
- ORD 기록
- ord-b591a05082434a8e9fc939d53a9b051d
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481540B2
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