Cesium carbonate → Acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-{1-methyl-5-[6-((1S,4S)-5-methyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-pyridazin-3-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzyl ester

반응식

[CH3:1][N:2]1[CH2:7][C@@H:6]2[CH2:8][C@H:3]1[CH2:4][N:5]2[C:9]1[N:14]=[N:13][C:12]([NH2:15])=[CH:11][CH:10]=1.Br[C:17]1[C:22](=[O:23])[N:21]([CH3:24])[N:20]=[C:19]([C:25]2[CH:35]=[CH:34][CH:33]=[C:32]([N:36]3[N:45]=[CH:44][C:43]4[C:38](=[C:39]([F:50])[CH:40]=[C:41]([C:46]([CH3:49])([CH3:48])[CH3:47])[CH:42]=4)[C:37]3=[O:51])[C:26]=2[CH2:27][O:28][C:29](=[O:31])[CH3:30])[CH:18]=1.CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.C(=O)([O-])[O-].[Cs+].[Cs+]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[C:46]([C:41]1[CH:42]=[C:43]2[C:38](=[C:39]([F:50])[CH:40]=1)[C:37](=[O:51])[N:36]([C:32]1[CH:33]=[CH:34][CH:35]=[C:25]([C:19]3[CH:18]=[C:17]([NH:15][C:12]4[N:13]=[N:14][C:9]([N:5]5[CH2:4][C@@H:3]6[CH2:8][C@H:6]5[CH2:7][N:2]6[CH3:1])=[CH:10][CH:11]=4)[C:22](=[O:23])[N:21]([CH3:24])[N:20]=3)[C:26]=1[CH2:27][O:28][C:29](=[O:31])[CH3:30])[N:45]=[CH:44]2)([CH3:47])([CH3:48])[CH3:49]