5-Methyl-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine → 5-methyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-2-amine

HRID 449683노트

반응식

HRID 449683 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]2[N:8]=[C:9]([N+:11]([O-])=O)[CH:10]=[C:4]2[CH2:3]1>C(O)C.[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]2[N:8]=[C:9]([NH2:11])[CH:10]=[C:4]2[CH2:3]1

참가 물질

4

반응물 1

HCID 580440245-Methyl-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine

생성물 1

HCID 580439335-methyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-2-amine수율 127.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 5-methyl-2-nitro-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine (67 mg, 0.37 mmol) in ethanol (15 mL) was treated with palladium on carbon (10%, 20 mg) and flushed with argon. The resulting mixture was stirred under a hydrogen (1 atm) overnight. The reaction mixture was filtered through a celite pad, and the pad washed with ethanol. The filtrate was concentrated in vacuo to give 5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-amine (72 mg, quantitative) as a light yellow oil.

후처리

  1. customflushed with argon
  2. filtrationThe reaction mixture was filtered through a celite pad
  3. washthe pad washed with ethanol
  4. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-55715437a3004b87afe1a23dafb5d23a
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481540B2

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