Methyl 4-((tert-butoxycarbonyl)amino)-2,6-dichlorobenzoate → Methyl 4-amino-2,6-dichlorobenzoate

반응식

C(OC([NH:8][C:9]1[CH:18]=[C:17]([Cl:19])[C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:11]([Cl:20])[CH:10]=1)=O)(C)(C)C>OS(O)(=O)=O.CCOC(C)=O>[NH2:8][C:9]1[CH:10]=[C:11]([Cl:20])[C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:17]([Cl:19])[CH:18]=1

참가 물질

실험 절차

A solution of methyl 4-(tert-butoxy carbonylamino)-2,6-dichlorobenzoate (65 g, 0.49 mol) in H2SO4/EtOAc (3 N, 20 mL) was stirred at room temperature for 2 hours. The reaction mixture was filtered, and the solid was collected to afford methyl 4-amino-2,6-dichlorobenzoate (60 g, yield: 92%). 1H NMR (DMSO-d6, 400 MHz) δ 8.40 (brs, 3H), 6.61 (s, 2H), 3.80 (s, 3H).

후처리

filtrationThe reaction mixture was filtered
customthe solid was collected

출처 및 근거

ORD 기록: ord-bb69f6630e0b45ebb44fc9a1d6c46dec
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08486950B2

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참가 물질

반응물 1

HCID 20610066Methyl 4-((tert-butoxycarbonyl)amino)-2,6-dichlorobenzoate

생성물 1

HCID 51341879Methyl 4-amino-2,6-dichlorobenzoate수율 92%

시약·촉매·용매 1

HCID 86628183Ethyl acetate sulfuric acid용매

실험 절차

후처리

filtrationThe reaction mixture was filtered
customthe solid was collected

출처 및 근거

ORD 기록: ord-bb69f6630e0b45ebb44fc9a1d6c46dec
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08486950B2

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불러오는 중…