Thionyl Chloride → 2,6-Dichloro-4-(dimethylcarbamoyl)benzoyl chloride

HRID 449924노트

반응식

HRID 449924 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:15])[N:12]([CH3:14])[CH3:13])[CH:8]=[C:7]([Cl:16])[C:3]=1[C:4](O)=[O:5].O=S(Cl)[Cl:19]>>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:15])[N:12]([CH3:14])[CH3:13])[CH:8]=[C:7]([Cl:16])[C:3]=1[C:4]([Cl:19])=[O:5]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 671288872,6-Dichloro-4-(dimethylcarbamoyl)benzoic acid

생성물 1

HCID 866489622,6-Dichloro-4-(dimethylcarbamoyl)benzoyl chloride수율 100%

실험 절차

A solution of 2,6-dichloro-4-(dimethylcarbamoyl)benzoic acid (65 mg, 0.21 mmol) in SOCl2 (3 mL) was heated to reflux for overnight and then cooled to room temperature. The mixture was concentrated under reduced pressure to give crude 2,6-dichloro-4-(dimethylcarbamoyl)benzoyl chloride (70 mg, yield: 100%), which was used in the next step without further purification.

후처리

  1. temperatureto reflux for overnight
  2. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4d307f5cca2e408dab15fb76c86b15f4
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486950B2

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