참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | Isoamyl Nitrite | HCID 8053 | — |
| 반응물 | 1H-Indazole | HCID 9221 | — |
| 반응물 | 1,4-Dibromo-2-nitrobenzene | HCID 77004 | — |
| 반응물 | Ethyl 6-bromobenzo[d]isoxazole-3-carboxylate | HCID 53401270 | — |
| 생성물 | 1,2-Benzisoxazole | HCID 71073 | — |
| 생성물 | Ethyl 1,2-benzoxazole-3-carboxylate | HCID 14177940 | — |
반응 단계
The benzisoxazole-, benzisoxazole-, and benzothiazolecarboxylic acids were prepared using similar strategies outlined for the indazole acids. For example, ethyl 6-bromobenzisoxazole-3-carboxylate was prepared from 2,5-dibromonitrobenzene by reaction with diethyl malonate, saponification and decarboxylation, and reaction with isoamylnitrite. Ethyl benzisoxazole-3-carboxylate was obtained by hydrogenolysis of the 6-bromo derivative. 4-Benzothiazolecarboxylic acid was prepared from 2-amino-4-chloro-benzothiazole by reaction with isoamyl nitrite followed by metal-halogen exchange and trapping with carbon dioxide. 5-Benzothiazolecarboxylic acid was prepared from 4-chloro-3-nitrobenzoic acid by reaction with Na2S and sodium hydroxide followed by reduction with zinc in formic acid. 3-Benzisothiazolecarboxylic acid was prepared from thiophenol by reaction with oxalyl chloride and aluminum chloride followed by treatment with hydroxylamine, hydrogen peroxide, and sodium hydroxide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08486937B2 |
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| 출처 데이터셋 | uspto-grants-2013_07 |
|---|
| ORD ID | ord-3f1b1888999b4e88a1da455fa9c79bc1 |
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| 출처 메모 | uspto-grants-2013_07 |
|---|
