Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 45생성일: 2026년 10월 23일
1-Ethylpiperazine → 8-[1-(4-Ethylpiperazin-1-yl)dibenzothiophen-4-yl]-2-morpholin-4-ylchromen-4-one
https://huagongshe.com/ko/reaction/45
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Ethylpiperazine | HCID 79196 | — |
| 반응물 | HCID 178418224 | HCID 178418224 | — |
| 시약 | Cesium carbonate | HCID 10796 | — |
| 촉매 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 8-[1-(4-Ethylpiperazin-1-yl)dibenzothiophen-4-yl]-2-morpholin-4-ylchromen-4-one | HCID 42644318 | 0% |
반응 단계
8-(1-iododibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one (20 mg, 0.04 mmol), 1-ethylpiperazine (9.42 µl, 0.07 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (2.145 mg, 3.71 µmol), TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM (0.849 mg, 0.93 µmol) and 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine (16.62 µl, 0.11 mmol) were suspended in dioxane (250 µl) and sealed into a microwave tube. The reaction was degased, purged with argon and heated to 130 °C over a period of 45 minutes in the microwave reactor. No reaction.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-8dc05311ad5340e693477414d5741a5e |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
