Diethyl Ether → 2-Bromo-1-(3-methylphenyl)ethan-1-one

HRID 450025

반응식

HRID 450025 반응식
[C:1]1([CH3:10])[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=[O:9])[CH3:8])[CH:2]=1.[Br:11]Br.CCOCC>O1CCOCC1>[Br:11][CH2:8][C:7]([C:3]1[CH:2]=[C:1]([CH3:10])[CH:6]=[CH:5][CH:4]=1)=[O:9]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 114553-MethylacetophenoneHCID 24408Bromine

생성물 1

HCID 100361292-Bromo-1-(3-methylphenyl)ethan-1-one

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of 1-m-tolyl-ethanone (6.0 g, 44.72 mmol) in dioxane (5 ml), bromine (7.14 g, 44.72 mmol) in dioxane (10 ml) and ether (15 ml) was added and stirred at room temperature for 5 hr. The reaction mixture was poured into ice water and the compound was extracted using ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate, filtered and then evaporated to give crude 2-bromo-1-m-tolyl-ethanone, 7.6 g (80%). The crude compound obtained was used in the next step without further purification.

후처리

  1. extractionthe compound was extracted
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customto give crude 2-bromo-1-m-tolyl-ethanone, 7.6 g (80%)

출처 및 근거

ORD 기록
ord-0586c48dda1c4b35beae4608fb38fbc0
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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