Oxalyl chloride → HCID 86621147, 화합물

HRID 450028노트

반응식

HRID 450028 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[C:8]2[N:13]([CH:14]=1)[CH:12]=[CH:11][CH:10]=[CH:9]2.[C:15](Cl)(=[O:19])[C:16]([Cl:18])=[O:17]>C1COCC1>[O:19]=[C:15]([C:14]1[N:13]2[C:8]([CH:9]=[CH:10][CH:11]=[CH:12]2)=[CH:7][C:6]=1[C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[C:16]([Cl:18])=[O:17]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 8530432-(Thiophen-2-yl)indolizine

생성물 1

HCID 86621147HCID 86621147, 화합물수율 41.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To an ice-cold solution of 2-thiophen-2-yl-indolizine (0.5 g, 2.51 mmol) in THF (8 ml) was added oxalyl chloride (0.3 ml, 3.48 mmol). The reaction mixture was stirred at room temperature for 30 min. The solvent was evaporated under vacuum. The crude product was recrystallized from dichloromethane-hexane to give oxo-(2-thiophen-2-yl-indolizin-3-yl)-acetyl chloride (0.3 g, 41%).

후처리

  1. customThe solvent was evaporated under vacuum
  2. customThe crude product was recrystallized from dichloromethane-hexane

출처 및 근거

ORD 기록
ord-9b40d8e8cbf541d5b5b5a4a43c84107b
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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