Methanol → Methyl 3-thiophenecarboxylate

HRID 450029

반응식

HRID 450029 반응식
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=[O:7])=[CH:2]1.S(=O)(=O)(O)O.[CH3:14]O>>[CH3:14][O:7][C:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)=[O:8]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 6918Thiophene-3-carboxylic acid

생성물 1

HCID 574151Methyl 3-thiophenecarboxylate수율 81%

실험 절차

To a solution of 3-thiophene carboxylic acid (2.0 g, 15.60 mmol) in methanol (30 ml) was added a catalytic amount of sulphuric acid (0.5 ml) and the reaction mixture was heated to reflux for 2 hr. The solvent was removed under reduced pressure and the residue was poured into ice-cold water and extracted with ethyl acetate. The organic layer was washed with water, concentrated and dried to give 3-thiophene carboxylic acid methyl ester (1.8 g, 81%).

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 2 hr
  3. customThe solvent was removed under reduced pressure
  4. additionthe residue was poured into ice-cold water
  5. extractionextracted with ethyl acetate
  6. washThe organic layer was washed with water
  7. concentrationconcentrated
  8. customdried

출처 및 근거

ORD 기록
ord-10910fa6af4a4957abcc8aa7951d8f77
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

연결된 노트

불러오는 중…