Ammonia → 4-Aminobenzamide

HRID 450033

반응식

HRID 450033 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH3:11]>O1CCCC1>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:11])=[O:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 177720Benzoyl chloride, 4-amino-

생성물 1

HCID 760794-Aminobenzamide수율 30%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To an ice-cold solution of 4-amino-benzoyl chloride (0.38 g, 2.45 mmol) in tetrahydrofuran (2 ml) was added aqueous ammonia solution (15 ml). The reaction mixture was stirred at room temperature for 12 hr. The solvent was removed under vacuum, water added and the compound was extracted into ethyl acetate. The organic layer was dried and concentrated under vacuum. The crude compound was purified using silica gel column chromatography, using chloroform/methanol as eluent, to yield 4-amino-benzamide (0.1 g, 30%).

후처리

  1. customThe solvent was removed under vacuum, water
  2. additionadded
  3. extractionthe compound was extracted into ethyl acetate
  4. customThe organic layer was dried
  5. concentrationconcentrated under vacuum
  6. customThe crude compound was purified

출처 및 근거

ORD 기록
ord-77b9532ce9694d63ae78c3ee0bbc54e6
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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