N-(4-Nitrophenyl)pyridin-2-amine → N-pyridin-2-yl-benzene-1,4-diamine

HRID 450065노트

반응식

HRID 450065 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:6][CH:5]=1)([O-])=O>C(OCC)(=O)C>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[NH:10][C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

참가 물질

3

반응물 1

HCID 12695755N-(4-Nitrophenyl)pyridin-2-amine

생성물 1

HCID 10375156N-pyridin-2-yl-benzene-1,4-diamine수율 33.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of (4-nitro-phenyl)-pyridin-2-yl-amine (280 mg, 1.3 mmol) in ethyl acetate (10 ml) was added stannous chloride dihydrate (1.17 g, 5.2 mmol) and stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate and washed with 10% sodium hydroxide solution. The organic layer was separated, washed with brine, dried and evaporated to dryness. Purification by column chromatography using ethyl acetate/hexane (2:3) yielded N-pyridin-2-yl-benzene-1,4-diamine (80 mg, 33%).

후처리

  1. washwashed with 10% sodium hydroxide solution
  2. customThe organic layer was separated
  3. washwashed with brine
  4. customdried
  5. customevaporated to dryness
  6. customPurification by column chromatography

출처 및 근거

ORD 기록
ord-20b74450bf6e4cebb4f88ac854b99de8
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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