(4-Nitrophenyl)acetic acid → Benzeneacetyl chloride, 4-nitro-

HRID 450077

반응식

HRID 450077 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)([Cl:16])=O>C1C=CC=CC=1>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([Cl:16])=[O:13])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 4661(4-Nitrophenyl)acetic acidHCID 24386Thionyl Chloride

생성물 1

HCID 6452210Benzeneacetyl chloride, 4-nitro-수율 91%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To mixture of p-nitrophenylacetic acid (1 g, 5.5 mmol) in benzene (10 ml) was added thionyl chloride (0.8 ml) at room temperature. The reaction mixture was heated to reflux for 12 hr and then cooled. The excess thionyl chloride and benzene were removed in vacuo to obtain (4-nitro-phenyl)-acetyl chloride (1 g, 91%).

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 12 hr
  3. temperaturecooled
  4. customThe excess thionyl chloride and benzene were removed in vacuo

출처 및 근거

ORD 기록
ord-f9c31a1a115c401fa9f3dac308421650
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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