1-(4-Nitrophenyl)propan-2-one → 4-Aminophenylacetone

HRID 450079

반응식

HRID 450079 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](=[O:13])[CH3:12])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11](=[O:13])[CH3:12])=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 2193671-(4-Nitrophenyl)propan-2-one

생성물 1

HCID 117883794-Aminophenylacetone수율 48%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1-(4-nitro-phenyl)-propan-2-one (150 mg) was dissolved in methanol (5 ml) and then Pd/C (50 mg) was added. The resulting reaction mixture was stirred for 10 hr at room temperature under hydrogen pressure. The reaction mixture was filtered over celite and the filtrate evaporated. Purification by column chromatography over silica gel using ethyl acetate and hexane (1:9) as eluent gave 1-(4-amino-phenyl)-propan-2-one (60 mg, 48%).

후처리

  1. customThe resulting reaction mixture
  2. filtrationThe reaction mixture was filtered over celite
  3. customthe filtrate evaporated
  4. customPurification by column chromatography over silica gel

출처 및 근거

ORD 기록
ord-a0e0548b7b274966b0f7a67c197f26de
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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