1-(4-Nitrophenyl)propan-2-one → 4-Aminophenylacetone
반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](=[O:13])[CH3:12])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11](=[O:13])[CH3:12])=[CH:8][CH:9]=1참가 물질
4
실험 절차
1-(4-nitro-phenyl)-propan-2-one (150 mg) was dissolved in methanol (5 ml) and then Pd/C (50 mg) was added. The resulting reaction mixture was stirred for 10 hr at room temperature under hydrogen pressure. The reaction mixture was filtered over celite and the filtrate evaporated. Purification by column chromatography over silica gel using ethyl acetate and hexane (1:9) as eluent gave 1-(4-amino-phenyl)-propan-2-one (60 mg, 48%).
후처리
- customThe resulting reaction mixture
- filtrationThe reaction mixture was filtered over celite
- customthe filtrate evaporated
- customPurification by column chromatography over silica gel
출처 및 근거
- ORD 기록
- ord-a0e0548b7b274966b0f7a67c197f26de
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08486962B2
반응 노트
불러오는 중…