Triethylamine → N-(4-Methylphenyl)-alpha-oxo-2-phenyl-3-indolizineacetamide

HRID 450105노트

반응식

HRID 450105 반응식
[O:1]=[C:2]([C:6]1[N:14]2[C:9]([CH:10]=[CH:11][CH:12]=[CH:13]2)=[CH:8][C:7]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:3](Cl)=[O:4].C([N:23]([CH2:26][CH3:27])CC)C>ClCCl>[O:1]=[C:2]([C:6]1[N:14]2[C:9]([CH:10]=[CH:11][CH:12]=[CH:13]2)=[CH:8][C:7]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:3]([NH:23][C:26]1[CH:27]=[CH:8][C:7]([CH3:15])=[CH:6][CH:2]=1)=[O:4]

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 50082602-oxo-2-(2-phenylindolizin-3-yl)acetyl Chloride

생성물 1

HCID 2905584N-(4-Methylphenyl)-alpha-oxo-2-phenyl-3-indolizineacetamide수율 128.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To an ice-cold solution of oxo-(2-phenyl-indolizin-3-yl)-acetyl chloride (0.5 g, 1.76 mmol) and p-toludine (0.21 g, 1.94 mmol) in dichloromethane (10 ml) was added triethylamine (0.5 ml, 3.52 mmol). The reaction mixture was stirred at room temperature for 1 hr. The solvent was evaporated under vacuum. Column chromatography on silica gel afforded 2-oxo-2-(2-phenyl-indolizin-3-yl)-N-p-tolyl-acetamide (0.4 g, 65%).

후처리

  1. customThe solvent was evaporated under vacuum

출처 및 근거

ORD 기록
ord-fe7cede7575e49ac89a2acf9f104d0a7
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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