Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzophenone oxime → diphenyl-methanone O-(2-dimethylaminoethyl)-oxime
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzophenone oxime | HCID 11324 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | diphenyl-methanone O-(2-dimethylaminoethyl)-oxime | HCID 10659548 | 26.1% |
반응 단계
To a solution of diphenyl-methanone oxime (2 g, 10 mmol) and (2-chloro-ethyl)-dimethyl-amine hydrochloride (1.5 g, 10.4 mmol) in DMSO (20 ml) was added powdered potassium hydroxide (800 mg, 14.3 mmol) and the reaction mixture stirred overnight. The reaction mixture was diluted with water and then extracted with ethyl acetate. The organic layer was washed thoroughly with water and brine, then dried over anhydrous sodium sulphate and filtered. Concentration of the organic layer under reduced pressure gave diphenyl-methanone O-(2-dimethylaminoethyl)-oxime (700 mg, 26%) as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08486962B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-421b1d16853c4246955cf68f76229eb0 |
| 출처 메모 | uspto-grants-2013_07 |