Benzophenone oxime → diphenyl-methanone O-(2-dimethylaminoethyl)-oxime

HRID 450107

반응식

HRID 450107 반응식
[C:1]1([C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][OH:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.Cl[CH2:18][CH2:19][N:20]([CH3:22])[CH3:21].[OH-].[K+]>CS(C)=O.O>[CH3:21][N:20]([CH3:22])[CH2:19][CH2:18][O:9][N:8]=[C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 11324Benzophenone oximeHCID 14797Potassium HydroxideHCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

생성물 1

HCID 10659548diphenyl-methanone O-(2-dimethylaminoethyl)-oxime수율 26.1%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

To a solution of diphenyl-methanone oxime (2 g, 10 mmol) and (2-chloro-ethyl)-dimethyl-amine hydrochloride (1.5 g, 10.4 mmol) in DMSO (20 ml) was added powdered potassium hydroxide (800 mg, 14.3 mmol) and the reaction mixture stirred overnight. The reaction mixture was diluted with water and then extracted with ethyl acetate. The organic layer was washed thoroughly with water and brine, then dried over anhydrous sodium sulphate and filtered. Concentration of the organic layer under reduced pressure gave diphenyl-methanone O-(2-dimethylaminoethyl)-oxime (700 mg, 26%) as a solid.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed thoroughly with water and brine
  3. dry with materialdried over anhydrous sodium sulphate
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-421b1d16853c4246955cf68f76229eb0
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

연결된 노트

불러오는 중…