Water → 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

HRID 450298노트

반응식

HRID 450298 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH2:7])=[N:3]1.[CH2:8]([CH2:12][C:13](=O)[CH3:14])[C:9]([CH3:11])=O.O>C1(C)C=CC=CC=1.CC(O)=O>[CH3:14][C:13]1[N:7]([C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=2)[C:9]([CH3:11])=[CH:8][CH:12]=1

참가 물질

6

반응물 3

HCID 962Water2회HCID 80352,5-HexanedioneHCID 1372541-Methyl-3-aminopyrazole

생성물 1

HCID 132489953-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 1140Toluene용매

실험 절차

To a solution of 1-methyl-1H-pyrazol-3-amine (9.5 g, 98 mmol) and acetonylacetone (11.2 g, 98 mmol) in toluene (150 mL), AcOH (1.5 mL) is added, heated to reflux with a water separator until the formation of water ceased. Concentrated to dry. The residue is purified by flash column to give product.

후처리

  1. temperatureheated
  2. concentrationConcentrated
  3. customto dry
  4. customThe residue is purified by flash column
  5. customto give product

출처 및 근거

ORD 기록
ord-c897f6aec06f4231b6a1c86ee56bc81c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486954B2

반응 노트

불러오는 중…