Ammonia → 2,4-Dichloro-5-fluoro-3-nitrobenzamide

HRID 450329

반응식

HRID 450329 반응식
[NH3:1].[Cl:2][C:3]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10]([Cl:15])[C:9]([F:16])=[CH:8][C:4]=1[C:5](Cl)=[O:6]>C1COCC1>[Cl:2][C:3]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10]([Cl:15])[C:9]([F:16])=[CH:8][C:4]=1[C:5]([NH2:1])=[O:6]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 11818130Benzoyl chloride, 2,4-dichloro-5-fluoro-3-nitro-

생성물 1

HCID 866744942,4-Dichloro-5-fluoro-3-nitrobenzamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

32%-aq. NH3-solution (250 mL) is dropped to 2,4-dichloro-5-fluoro-3 nitro-benzoic acid chloride (16.0 g, 59 mmol) in 100 mL THF and it is stirred for 20 min. Then the mixture is concentrated and the resulting precipitate is collected and dried.

후처리

  1. concentrationThen the mixture is concentrated
  2. customthe resulting precipitate is collected
  3. customdried

출처 및 근거

ORD 기록
ord-df08f57c65574d2dac6a5cf4ec7a4982
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486968B2

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