Ammonia → 5-(3-(Pyridin-3-yl)-1,2,4-oxadiazol-5-yl)pyridin-3-ol

반응식

[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[OH:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([CH:20]=1)[C:17](O)=O.N>>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([C:3]2[N:10]=[C:17]([C:16]3[CH:20]=[C:12]([OH:11])[CH:13]=[N:14][CH:15]=3)[O:1][N:2]=2)[CH:5]=1

참가 물질

반응물 3

HCID 222Ammonia

HCID 340375-Hydroxynicotinic acid

HCID 308113N-Hydroxynicotinimidamide

생성물 1

HCID 597587445-(3-(Pyridin-3-yl)-1,2,4-oxadiazol-5-yl)pyridin-3-ol

실험 절차

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 5-hydroxynicotinic acid (Matrix Scientific). 1H NMR (300 MHz, DMSO-d6) δ 7.66 (ddd, J=8.0, 4.9, 1.0 Hz, 1 H), 7.86 (dd, J=2.7, 2.0 Hz, 1 H), 8.31-8.55 (m, 2 H), 8.83 (s, 2 H), 9.26 (s, 1 H) ppm; MS (DCI/NH3) m/z 241 (M+H)+.

출처 및 근거

ORD 기록: ord-e49df828d97b4c79823e8d4198a1179f
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08486979B2

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