Ammonia → 5-(3,5-Difluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole

HRID 450603

반응식

[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([F:21])[CH:20]=1)[C:15](O)=O.N>>[F:11][C:12]1[CH:13]=[C:14]([C:15]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[N:10]=2)[CH:18]=[C:19]([F:21])[CH:20]=1

참가 물질

반응물 3

HCID 222Ammonia

HCID 1012653,5-Difluorobenzoic acid

HCID 308113N-Hydroxynicotinimidamide

생성물 1

HCID 670260715-(3,5-Difluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole

실험 절차

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3,5-difluorobenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.37 (tt, J=9.0, 2.3 Hz, 1 H), 7.65 (ddd, J=7.9, 5.0, 1.0 Hz, 1 H), 7.82-7.91 (m, 2 H), 8.56 (dt, J=7.9, 2.0 Hz, 1 H), 8.75 (dd, J=4.8, 1.6 Hz, 1 H), 9.30 (dd, J=2.0, 0.8 Hz, 1 H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.

출처 및 근거

ORD 기록: ord-df9fa8ebab1049869e9dbd1cab715a16
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08486979B2

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