Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-5-nitro-3-(trifluoromethyl)pyridine → 5-(Trifluoromethyl)pyridin-3-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine | HCID 3849140 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-(Trifluoromethyl)pyridin-3-amine | HCID 14051936 | — |
반응 단계
A mixture of 2-chloro-5-nitro-3-trifluoromethyl-pyridine (30 mg, 0.13 mmol), 10% Pd/C (3 mg, 10% w/w), and MeOH (5 mL) is stirred under 1 atm of hydrogen for 3 h. The mixture is then filtered over Celite® and concentrated in vacuo to give the title compound as an oil. MS (ESI) m/z 162.9 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541432B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-3b6178c4a1d045a29eced0ae97e978c8 |
| 출처 메모 | uspto-grants-2013_09 |