Ammonia → Tert-butyl 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzylcarbamate

HRID 450644

반응식

HRID 450644 반응식
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[C:11]([O:15][C:16]([NH:18][CH2:19][C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23](O)=O)=[O:17])([CH3:14])([CH3:13])[CH3:12].N>>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([C:3]2[N:10]=[C:23]([C:22]3[CH:21]=[C:20]([CH:28]=[CH:27][CH:26]=3)[CH2:19][NH:18][C:16](=[O:17])[O:15][C:11]([CH3:14])([CH3:12])[CH3:13])[O:1][N:2]=2)[CH:5]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 27559293-(((tert-Butoxycarbonyl)amino)methyl)benzoic acid

생성물 1

HCID 67026201Tert-butyl 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzylcarbamate

실험 절차

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3-((tert-butoxycarbonylamino)methyl)benzoic acid (Fluka). 1H NMR (300 MHz, DMSO-d6) δ 1.42 (s, 9 H), 4.27 (d, J=6.1 Hz, 2 H), 7.51-7.72 (m, 4 H), 8.01-8.17 (m, 2 H), 8.45 (dt, J=8.1, 1.9 Hz, 1 H), 8.82 (dd, J=5.1, 1.7 Hz, 1H), 9.26 (dd, J=2.2, 0.8 Hz, 1 H) ppm; MS (DCI/NH3) m/z 353 (M+H)+.

출처 및 근거

ORD 기록
ord-51de86c2367b43f9a0bd730cba7e425a
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486979B2

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