Ammonia → 3-(Pyridazin-4-yl)-5-(2,3,4-trifluorophenyl)-1,2,4-oxadiazole

반응식

[OH:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][N:8]=[N:7][CH:6]=1)[NH2:4].[F:11][C:12]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[CH:17][C:13]=1[C:14](Cl)=O.N>>[N:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:4]=[C:14]([C:13]3[CH:17]=[CH:18][C:19]([F:22])=[C:20]([F:21])[C:12]=3[F:11])[O:1][N:2]=2)=[CH:6][N:7]=1

참가 물질

반응물 3

HCID 222Ammonia

HCID 27340222,3,4-Trifluorobenzoyl chloride

HCID 136140373N-Hydroxy-4-pyridazinecarboximidamide

생성물 1

HCID 445447733-(Pyridazin-4-yl)-5-(2,3,4-trifluorophenyl)-1,2,4-oxadiazole

실험 절차

The titled compound was prepared according to the procedure of Method D using the product of Example 83D and 2,3,4-trifluorobenzoyl chloride (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.40-7.50 (m, J=9.3, 9.3, 7.0, 2.2 Hz, 1 H), 8.10-8.20 (m, 1 H), 8.39 (dd, J=5.4, 2.4 Hz, 1 H), 9.46 (dd, J=5.3, 1.2 Hz, 1 H), 9.87 (dd, J=2.2, 1.2 Hz, 1 H) ppm; MS (DCI/NH3) m/z=279 (M+H)+.

출처 및 근거

ORD 기록: ord-bc0e7bb9e8604021b4b12e0edd31f82a
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08486979B2

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